Testicular Germ Cell Tumors with Somatic-type Malignancy

Testicular cancer accounts for ∼1% of all cancers in men worldwide, with over 90% testicular being germ cell tumors (GCTs). Since the introduction multimodal therapy, GCTs have been among most curable solid tumors. However, some patients may develop late relapse, which is defined as recurrence at least two years after initial complete remission. Late particularly common teratomatous and associated somatic-type malignancy (SM) development. Approximately 2.5–8.0% GCT SM, a distinct secondary component that resembles seen other organs tissues. The histological subtypes SM are diverse show morphological features sarcomas, carcinomas, embryonic-type neuroectodermal tumors, nephroblastomas, hematologic malignancies, or combination different forms. Several studies demonstrated development GCTs, metastatic sites, poor prognosis. In current review, we discuss concept diagnostic criteria, subtypes, pathogenesis, clinical outcomes SM.